Bringing Extinct Species Back to Life | Dr. Beth Shapiro

让灭绝物种重获新生 | 贝丝·夏皮罗博士

Huberman Lab

2026-10-05

2 小时 15 分钟
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Dr. Beth Shapiro, PhD, is an evolutionary biologist and Chief Science Officer at Colossal Biosciences. Her work focuses on de-extinction and wildlife conservation efforts. We discuss genetic differences among humans, and how ancient DNA and modern embryology are being used to de-extinct and protect woolly mammoths, dodo birds, and dire wolves, as well as to help conserve endangered species. We also explore the ethical implications of de-extinction and how synthetic biology can help build a more bio diverse and resilient world. Read the full episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Beth Shapiro (00:02:35) What is a Species?, Taxonomy, Bison (00:09:13) Neanderthals, Denisovans, Homo Sapiens (00:12:38) Sponsors: Joovv & Eight Sleep (00:15:27) Hybrid Ancestry, “Grolar” Bears (00:20:30) Homo Sapiens & Neanderthal Interbreeding, Genes; Denisovans (00:25:53) Neanderthal Genes, Immunity, Red Hair; Eye Color (00:30:17) De-Extinction, Species Selection, Woolly Mammoths (00:38:08) Sponsor: AG1 (00:39:21) Bird De-Extinction, Dodo; Reproduction & Genes (00:47:40) Development Biology, Woolly Mammoth, Elephants (00:54:49) Dire Wolf, Synthetic Biology, Ethics (01:03:26) De-Extinction, Ecology, Conservation, Ethics (01:09:22) Ecosystem Resilience, Thylacine; Preventing Extinction, Quolls (01:15:45) Sponsor: Function (01:17:23) Modeling Ecological Impact, Mosquitoes, Gene Drives; Panthers (01:25:50) Advisory Panels, Synthetic Biology Education (01:29:13) Genetic Selection in Humans, Human-Shaped World (01:38:25) Black-Footed Ferrets, Genetic Rescue (01:47:05) Dire Wolf; Ecological Modeling, New Technology & Public Fear (01:55:09) Artificial Wombs; Current Issues, Conservation & Red Wolf (02:01:26) Science Pioneers; Colossal Public Education (02:04:31) Beth’s Science Origin Story; Dinosaurs (02:13:42) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
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  • So our direwolves, they have 20 edits that we picked and we sequenced genomes from fossil direwolves.

  • We learned from those genomes what genetic changes made those animals bigger, more robust, light colored in coat.

  • And then we engineered those changes into a gray wolf genome to recreate the direwolf.

  • You know, I often get the question of why are you thinking about bringing extinct species back to life?

  • Why aren't you thinking about helping living species not become extinct?

  • And the answer is we are doing both.

  • It is the same tools.

  • It's the same technology.

  • It's the same needs.

  • And when we excite people with the idea of mammoths and dodos and thylacines, we get more engagement

  • and enthusiasm and investment in developing the technology that we can use to stop living species from becoming extinct.

  • Welcome to the Huberman Lab Podcast, where we discuss science and science-based tools for everyday life.

  • I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.

  • My guest today is Dr. Beth Shapiro.

  • Dr. Beth Shapiro is an evolutionary biologist.

  • She was a professor at UC Santa Cruz and an investigator with the Howard

  • Hughes Medical Institute before leaving to become chief scientific officer at Colossal Biosciences.

  • Her work at Colossal is focused on what is called de-extincting species such as the woolly mammoth, the dodo bird,

  • and the dire wolf, meaning bringing them back to life.

  • But that entire initiative is also about species preservation