Ancient DNA is uncovering the history of plague

古DNA重写瘟疫历史

Babbage from The Economist

2026-06-25

39 分钟
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Plague pandemics conjure images of dirty medieval cities. But new evidence has revealed the oldest known outbreak of the disease—more than 5,000 years ago—showing that dense settlements were not necessary for the bacteria to spread and become lethal. It is the latest example of how sequencing ancient genomes can open up a wealth of new data for archaeologists and historians. It is a technique that is rewriting the history of our species. Guests and hosts: Sam Wikeley, The Economist's science correspondentEske Willerslev of the University of Cambridge and the University of CopenhagenPontus Skoglund of the Francis Crick InstituteJulietta Steinhauer of University College LondonAlok Jha, The Economist's science and technology editor  Topics covered: Ancient DNAPlague pandemicsHistory Transcripts of our podcasts are available via economist.com/podcasts. Listen to what matters most, from global politics and business to science and technology—subscribe to Economist Podcasts+.
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  • The Black Death was one of the most deadly pandemics in human history.

  • It conjures up images of dirty medieval cities, infested by fleas and rats, people living in fear and panic.

  • This outbreak of plague is thought to have killed as many as 50 million people,

  • half the population of Europe at the time.

  • But it wasn't the first time that plague had ravaged the continent.

  • It had also spread around Europe nearly a thousand years before.

  • And according to a study published just last week,

  • the same bacterium had also been spreading between people in what is now Siberia more than 5,000 years ago.

  • That's the oldest known outbreak of plague.

  • And well before the emergence of any towns or closely packed settlements that are normally associated with the disease.

  • The finding comes from a relatively new field of research, something we've explored before on Babbage,

  • where scientists have been able to sequence the genomes inside ancient bones.

  • It's a technology that's opening up a wealth of new data for archaeologists and historians,

  • and it's rewriting the history of our species in the process.

  • I'm Alok Jav and this is Babbage from The Economist.

  • Today, what ancient plagues tell us about modern humans.

  • With me for today's show is Sam Whiteley, one of our science correspondents.

  • Sam, thanks for joining me.

  • Great to be here.

  • Now, Sam, when I think of plague, I'm thinking rats probably sort of foaming at the mouth,