Wake-up haul: an Ozempic moment for the brain

跌落神坛的日本

The Intelligence from The Economist

2026-08-19

22 分钟
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Orexins are peptides involved in the body's sleep-wake system—and are big pharma's next big thing. Like multi-purpose GLPs, they may have far more uses than just regulating shuteye. We ask why Japan's post-war innovation boom petered out, and what must be done to breed more unicorns. And why procrastination seems to be on the rise, and how to beat it. Guests and host: Shailesh Chitnis, global business correspondentEthan Wu, Asia business and finance editorBenjamin Sutherland, science writerRosie Blau, co-host of “The Intelligence”Jason Palmer, co-host of “The Intelligence” Topics covered:  orexins, peptides, sleep disorders, pharmaceuticalsJapan, innovation, startupsprocrastination Listen to what matters most, from global politics and business to science and technology—subscribe to The Economist.
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  • The Economist.

  • Hello and welcome to The Intelligence from The Economist.

  • I'm Jason Palmer.

  • And I'm Rosie Blau.

  • Today on the show, why Japan has had such a weak startup scene

  • and how to beat procrastination and just get on with it.

  • First up, though.

  • Let me take you back to Tokyo in 1946.

  • A young physicist named Morita Akio resigned from a teaching post at a top university

  • and co-founded the Tokyo Telecommunications Engineering Corporation

  • in a recently firebombed department store.

  • Our capital of $527 and a seven-man staff.

  • That was in fact all the resources we had with which to launch an enterprise.

  • Today you know that firm as Sony, and it's worth $140 billion.

  • That same year, Honda was launched out of a ruined factory.

  • As recently as the 1980s, SoftBank started as a small software distributor run by a 24-year-old.

  • This month it reported profits of more than $2 billion in a quarter.

  • These are survivorship-bias success stories, to be sure.

  • But something about entrepreneurship does seem to have changed.

  • Ever since the postwar period when Japan produced world-bestriding companies from scrappy origins,