The Vape Cloud Hanging Over the FDA

FDA上空缭绕的蒸汽云

The Journal.

2026-05-13

20 分钟
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Dr. Marty Makary has resigned as commissioner of the Food and Drug Administration. Makary faced criticism over the FDA’s rejections of rare-disease drugs, the agency’s handling of abortion pills and high-profile departures of key FDA staff. But WSJ’s Liz Essley Whyte reports that it was a battle over flavored vapes that sealed Makary’s fate. Jessica Mendoza hosts. Further Listening: - The Flu Shot Drama at the FDA - The FDA Boss on the Agency’s MAHA Makeover - How Puff Bar Became the Most Popular Vape for KidsSign up for WSJ’s free What’s News newsletter. Learn more about your ad choices. Visit megaphone.fm/adchoices
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  • The Food and Drug Administration saw a huge shakeup in leadership today.

  • Today, the FDA commissioner, Dr. Marty McCary, resigned.

  • And how big a deal is that?

  • I think it's a huge deal.

  • Our colleague Liz Esley-White covers health policy.

  • He had a tumultuous tenure full of intrigue and palace drama and politics and conflict in a way

  • that we have n't really seen with any other FDA commissioner.

  • President Trump called McCary, quote, a terrific guy, but added that he was having some difficulty.

  • McCary, a surgeon by training, was sworn in as commissioner over a year ago

  • with promises to usher in a new era at the FDA.

  • He started phasing out artificial food dyes and cut down on the time it takes for drugs to get FDA approval.

  • But McCary also faced a lot of headwinds throughout his tenure.

  • Patients, oncologists, and biotech investors have been pressing Commissioner McCary over a string of drug rejections,

  • none more contentious than Replimune.

  • He 's managed to make a lot of critics in the pharmaceutical industry who view him as unsympathetic

  • to the cause of rare disease patients.

  • I don't work for Replimune.

  • I work for the American people, and I stand by the scientists at the FDA.

  • The White House has also blamed McCary for a mess of bad PR from people he brought on who then quickly left the agency.

  • That's according to people familiar with the matter.