Immunometabolism, Inflammation, and Building Biotechs with Luke O'Neill

Luke O'Neill recounts his role in discovering key components of the TLR signaling pathway, explains how pursuing unexpected research questions keeps him motivated, and reflects on his experiences as an entrepreneur founding biotech companies. Host: Cindy Leifer Guest: Luke O'Neill Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server O'Neill lab Identification of MAL in the TLR signaling pathway (Nature, 2001) GDF 15, immunometabolism and anti-inflammatories (An Rev Pharmacol Tox, 2026) Itaconate and regulation of inflammation (Nat Metab, 2024) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.