Superbugs: Resistance Rising Part 2

超级细菌:耐药性加剧 第二部分

Discovery

2026-03-31

26 分钟
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The rapid spread of antibiotic resistant bacteria is already claiming lives - and a far greater global crisis is on the horizon. In this three part series for Discovery, reporter Roland Pease traces how we reached this point, uncovers the forces driving resistance ever faster, and meets the scientists racing to outpace evolving superbugs before our lifesaving medicines fail for good. Episode 2 - The chemists' challenge. With all the low-hanging fruit in the antibiotic search space gone, chemists are having to work harder and be cleverer to top up the antibiotic pipeline. The chances of finding even one successful compound in a working life are low, but can new approaches like AI or genetics make the difference?
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  • From a personal aspect, I had the wonderful opportunity back in 2007 of actually

  • meeting the very first child to take linazolid ever.

  • Steve Brickner is a medicinal chemist who had succeeded in bringing an entirely

  • new kind of antibiotic to market in the year 2000.

  • Though he'd already seen its power to cure.

  • She was dying from a vancomycin-resistant enterococcus infection.

  • You know, she was very seriously ill, and they knew that she was n't going to be around,

  • and there were no clinical trials then.

  • She took this drug on a compassionate use basis.

  • They made arrangements with the FDA and Upjohn to fly out.

  • You know, the drug in powder form.

  • They didn't even know how to give it to her because they couldn't get an IV in her.

  • She was that sick.

  • And this girl was two years old at the time she was treated with it, but she recovered completely.

  • At the time I met her in 2007, she was 11 years old, wonderful young lady, and she thanked us for saving her life.

  • And it was very, it was very moving.

  • I'm Roland Pease, and I 'd asked Dr Brickner in 2014 what it was like to know you 'd created a treatment with the power

  • to save thousands of lives that would otherwise be lost.

  • And I've never forgotten that reply.

  • It had taken, Dr Brickner, 13 years of testing and improving thousands of prototype compounds at Upton Pharmaceuticals