Essentials: Genes & the Inheritance of Memories Across Generations | Dr. Oded Rechavi

基因与代际间记忆传承的要素 | 奥德·雷查维博士

Huberman Lab

2026-09-10

35 分钟
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In this Huberman Lab Essentials episode, my guest is Dr. Oded Rechavi, a professor at Tel Aviv University who studies genetics, epigenetics and the inheritance of acquired traits. We discuss how DNA, RNA and epigenetic mechanisms determine what information can pass between generations, and why acquired traits are generally not thought to be inherited. We also explain research in C. elegans showing how small RNAs can transmit antiviral resistance and influence behavior across generations, what these findings might mean for mammals and humans, and potential future applications for reproductive health and diagnostics. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:00) Oded Rechavi (00:00:24) DNA, Genome, RNA & Proteins (00:03:43) Somatic vs. Germ Cells; Inheritance (00:06:05) Sponsor: Eight Sleep (00:07:23) Lamarck vs. Darwin, Inheritance of Acquired Traits (00:09:45) Weismann Barrier, Epigenetic Reprogramming (00:13:05) RNA & Transgenerational Inheritance (00:13:54) Model Organisms, C. elegans (00:16:59) Inheritance of Acquired Traits in C. elegans (00:17:14) Sponsor: AG1 (00:18:40) RNA Interference, Small RNAs & Gene Silencing (00:22:46) Viral Resistance Across Generations (00:24:53) Small RNAs, Mammals & Inherited Effects (00:26:00) Brain Activity, Memory & Heritable Information (00:28:46) Neuronal Small RNAs & Behavior Across Generations (00:29:59) Germ Cells, Development & Heritable RNA (00:31:29) Sponsor: LMNT (00:33:11) Future Applications, Exercise, IVF & RNA Diagnostics (00:35:16) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
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  • Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent

  • and actionable science-based tools for mental health, physical health, and performance.

  • I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.

  • And now for my discussion with Dr. Oded Rahavi.

  • Oded, thank you so much for being here.

  • Totally, my pleasure.

  • Today, what I mainly want to talk about is...

  • Incredible questions that you probe in your lab which are incredibly significant

  • for each and all of our lives i think most people have a general understanding

  • of what genes are what rna is and so on but maybe you could explain to people

  • in very basic terms and i'll just preface all this by saying that i think most people understand

  • that if they have two blue-eyed parents that there's a higher probability that they their offspring

  • will have blue eyes than brown eyes but most people generally understand and accept

  • that if they spend part of their life um let's say studying architecture that if they have children

  • that there's no real genetic reason we assume that their children would somehow be better at architecture

  • because they contain the knowledge through the dna of their parents they might be exposed

  • to it in the home so-called nature nurture also nurture in that case but that they wouldn't inherit knowledge

  • today i'm hoping you can explain to us why eye color but not knowledge is thought to be inherited

  • and the huge landscape of interesting questions that this opens up including some evidence

  • that Contrary to what we might think, certain types of knowledge at the level of cells and systems can be inherited.