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Hello and welcome to News Hour from the BBC World Service.
Coming to you live from London, I'm Rajini Vaidyanathan.
Thick plumes of black smoke rise above Tehran as the US and Israel strike an oil refinery and a depot in the capital.
The targeting of energy infrastructure for the first time is the latest escalation in this ongoing conflict.
In a moment we'll explore the health impacts.
Hundreds of other targets across Iran have also been struck.
Iran's Red Crescent says more than 1,300 people have now been killed since the war began.
Iran continues to retaliate, firing more drones and rockets at Israel,