How Your Immune System Works & How to Improve It | Dr. Max Krummel

免疫系统如何运作及如何增强它 | 马克斯·克鲁梅尔博士

Huberman Lab

2026-08-03

2 小时 27 分钟
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My guest is Dr. Matthew (Max) Krummel, PhD, professor at UCSF and one of the world’s leading immunologists. We discuss how your immune system works and how sleep, emotions, and even memories shape immune function. We also explore thymus function, its role in autoimmunity, and its potential role in combating cancer. And we discuss how the type and timing of immunization can impact health. This episode provides an actionable framework for understanding how your immune system works, which ought to benefit people of all ages and health statuses. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Joovv: https://joovv.com/huberman Timestamps (00:00:00) Max Krummel (00:02:18) Immune System, Immunotherapy (00:08:36) Illness, Childhood & Immune System (00:13:02) Aging & Immunity, DNA Mutations (00:18:36) Sponsors: Joovv & Eight Sleep (00:21:14) Self vs Non-Self Recognition, Aging, Cancer; Immune Surveillance (00:30:11) Cancer, Immune System, Age & Measuring Change (00:35:57) Thymus, T Cells; Aging & Cancer (00:42:13) Reproduction, Aging & Immune System; Basic Research (00:47:28) Sleep & Illness Susceptibility (00:52:55) Sponsor: AG1 (00:54:08) Umbilical Cord Banking; Organoids, CAR T Cells, Thymus (01:02:57) Scientific Curiosity, Failures, & Discovery (01:13:14) Spatial Biology & Immune Cells; Memory & Immune State; Stress, Meditation (01:25:00) Sponsor: Function (01:26:37) Mindset; Tissue Engineering, Peptides, Systems Biology (01:34:25) Immunizations in Childhood and Beyond (01:39:37) Pharmaceutical Companies, Public Distrust (01:49:22) Disease Risk, Immunity; Autism, Flu, (01:58:56) Biological Resilience, Cancer; Computational Research (02:08:02) Autoimmune Conditions, Asthma, IBD (02:13:34) Autoimmunity & Genetic Diversity Benefits (02:17:11) Science Communication, Max's Substack (02:24:07) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices
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  • A famous immunologist in the 1970s drew this parallel in wartime

  • and said in World War II, submarines had two sets of books.

  • One of them was a book that gave them the sound profile of all the U.S.

  • Submarines.

  • And so they could listen to the whir of the engines.

  • And if they heard a whir of the engine that had the certain cycle of a general motors engine, they wouldn't fire.

  • So that's the sort of like self, I know what self is.

  • And then they had another book that was the engine sounds

  • of the known diesel engines of whatever engines of the German submarines.

  • And if they heard that, then they absolutely would fire.

  • And that's a self versus non-self discrimination problem, just like the immune system has to do.

  • But what I bring you with aging is this concept

  • that as you get weirder and different, your body is getting like more complex.

  • Then those books, you know, start to have every possible,

  • possibly every possible permutation of every biomolecule could be made by your body at that point.

  • And then a virus doesn't necessarily have anything unique about it.

  • Welcome to the Huberman Lab podcast, where we discuss science and science-based tools for everyday life.

  • I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.

  • My guest today is Dr. Max Krummel, a professor

  • and leading expert in immunology and cancer biology at the University of California, San Francisco.