After weeks of military buildup, the U.S.
and Israel have launched a major combat operation in Iran.
It's a very simple message.
They will never have a nuclear weapon.
I'm Ayesha Roscoe.
And I'm Scott Simon and this is Up First from NPR News.
The Defense Department calls this mission Operation Epic Fury and has targeted Iran's leadership.
President Trump is calling on the Iranian people to, quote, take over your government.
In a moment, details from NPR's Greg Myhre.
Iran has retaliated by launching a missile attack on Israel.
Israel's air defense systems are responding.
We'll hear from our correspondents in the Middle East.
So please stay with us.
We've got the news you need to start your weekend.
Large explosions were reported in Tehran as the U.S.-Israeli military operation in Iran began early Saturday morning.
It followed weeks of escalating tension in the Middle East.
And paranational security correspondent Greg Myhre is with us.
Thanks for being with us, Greg.
Hi, Scott.
And what can you tell us about this military operation?