How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read Montague

多巴胺与血清素如何塑造决策、动机与学习 | 雷德·蒙塔古博士

Huberman Lab

2026-02-02

2 小时 41 分钟
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Dr. Read Montague, PhD, is a professor and director of the Center for Human Neuroscience Research at Virginia Tech and an expert in how dopamine and serotonin shape human learning, motivation and decision-making. We discuss how they impact focused effort in the context of short- and long-term goals of all kinds. Also, how SSRIs and low-effort, high-engagement activities reduce the rewarding properties of dopamine, and how AI algorithms are revolutionizing understanding of the brain. Episode show notes are available at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Joovv: https://joovv.com/huberman Function: https://functionhealth.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:00) Read Montague (00:02:54) Dopamine, Motivation & Learning (00:08:49) Reward Prediction Error, Expectations (00:12:24) Sponsors: David & Joovv (00:14:54) Foraging, Dating, Expectations vs Outcomes; AI (00:23:36) Dopamine, Expectation, Motivation; Forward Drive; Dopamine "Hits" (00:29:58) Baseline Dopamine & Fluctuations; Parkinson's Disease (00:34:36) Movement, Urgency; ADHD, Bee's Dance, Explorer vs Focus Mode (00:42:29) Sponsor: AG1 (00:43:40) Social Media, ADHD; Explorers vs Task-Based, Combat (00:50:54) Effort, Learning; Social Media & Phones, Resisting Behaviors (01:01:36) Serotonin & Dopamine, Opponency, SSRIs (01:11:21) Hunger, Dopamine; Negative Feedback, Learning, Trauma; Torture (01:18:34) Drugs of Abuse & High Dopamine (01:19:48) Sponsor: Function (01:21:35) Trauma & Dopamine Adaptation (01:27:34) SSRIs, Dopamine, Positive Experiences (01:29:50) Deep Brain Stimulation; Measuring Dopamine & Serotonin in Humans (01:36:16) Sleep; Divorce; Science is a Contact Sport (01:45:14) Long-Term Motivation, Learning How to Fail, Tool: Kids & Sports (01:54:14) Sponsor: LMNT (01:55:34) Meditation, Breathing, Learning; Dopamine as a Currency (02:04:38) Function of Sleep, Motivation; Time Perception & Dopamine, Tracking Time (02:13:18) LLMs, AI, Uses & Problem Solving (02:18:33) Future Projects, Commercial Brain-Machine Interfaces; Concentration (02:25:57) Dopamine "Hits"?; Depression & Schizophrenia; Quitting (02:30:17) Dopamine & Serotonin Misunderstandings; Internal Satisfaction; Motivation (02:35:58) Serotonin Syndrome; Acknowledgements (02:38:31) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
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  • If any goal that you achieved, whatever it is, taking a drug, eating a food,

  • getting a partner or whatnot, if that was enough for you, right then, you wouldn't keep living.

  • You want that system to keep tracking, and once it gets to one place,

  • you want it to have another place to which it could go, otherwise you wouldn't live.

  • Welcome to the Huberman Lab Podcast,

  • where we discuss science and science-based tools for everyday life.

  • I'm Andrew Huberman,

  • and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.

  • My guest today is Dr.

  • Reid Montague.

  • Dr.

  • Reid Montague is the director of the Center for Human Neuroscience Research at Virginia Tech.

  • He is also an expert in the science of motivation, decision-making, and learning,

  • and a pioneer in developing methods to directly measure levels of dopamine and other neuromodulators in humans in real time.

  • Today you'll learn how dopamine really works, not just to regulate your levels of motivation,

  • we've all heard that before, but also to teach you things.

  • Dopamine is involved in learning, as well as persistence or lack of persistence.

  • As Reid will teach you,

  • most of what we hear and know about dopamine is based on the idea that dopamine levels go up or down depending on our levels of expectations and then what happens.

  • But as he explains, most aspects of life, work, school,