#845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment)

#845:如何利用酮症提升情绪、认知和长期脑部保护——与多米尼克·达戈斯蒂诺博士的实用战术指南(附:蒂姆最新酮饮食实验解析)

The Tim Ferriss Show

2026-01-07

2 小时 21 分钟
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Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition. This episode is brought to you by: Gusto simple and easy payroll, HR, and benefits platform used by 400,000+ businesses: https://gusto.com/tim Seed's DS-01® Daily Synbiotic broad spectrum 24-strain probiotic + prebiotic: https://Seed.com/Tim David Protein Bars 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/tim Coyote the card game​, which I co-created with Exploding Kittens: https://coyotegame.com* For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast. For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsors Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday. For transcripts of episodes, go to tim.blog/transcripts. Discover Tim’s books: tim.blog/books. Follow Tim: Twitter: twitter.com/tferriss  Instagram: instagram.com/timferriss YouTube: youtube.com/timferriss Facebook: facebook.com/timferriss  LinkedIn: linkedin.com/in/timferriss See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Hello, boys and girls, ladies and germs.

  • This is Tim Ferriss.

  • Welcome to another episode of the Tim Ferriss Show.

  • This particular episode, I think, is probably my most practical, tactical discussion of ketosis,

  • what the benefits are, how to implement it, when the rubber hits the road, what do you do?

  • What do you do?

  • What do you try to avoid?

  • What are some of the challenges?

  • And this conversation with Dom D'Agostino, I'll describe him in a second,

  • took place about midway through a month-long experiment.

  • I've done a lot of ketogenic dieting.

  • I've experimented with it since probably the late 90s.

  • And my latest bout was one month wearing both a continuous glucose monitor and a continuous ketone monitor.

  • And we basically deconstructed it.

  • And I got Dom's advice on how to tweak it, how to fine tune it.

  • Now, why would you even want to consider ketosis?

  • And we also get into exogenous ketones, so supplemental ketones.

  • They become quite the topic du jour, quite popular among certain athletic populations and so on.

  • But we talk about toxicity.

  • with some of these supplements and what to look out for.