Essentials: Understanding & Conquering Depression

essentials:理解与战胜抑郁

Huberman Lab

2025-07-03

40 分钟
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单集简介 ...

In this Huberman Lab Essentials episode, I explore major depression, including its underlying biology and discuss science-based approaches to alleviate symptoms and improve mood. I describe the wide-ranging symptoms of depression and explain how key neurotransmitters, hormones, stress, genetics and inflammation contribute to its development and persistence. I also cover treatment options, from traditional classes of antidepressant medications to emerging therapies such as ketamine and psilocybin. Finally, I highlight lifestyle-based tools, including exercise, supplementation and dietary strategies that can help manage depressive symptoms and promote mental well-being. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Our Place: https://fromourplace.com/huberman Timestamps 00:00:00 Major Depression 00:01:10 Depression Symptoms 00:06:14 Sponsor: BetterHelp 00:07:33 Pharmaceuticals for Depression, SSRIs; Norepinephrine, Dopamine & Serotonin 00:14:33 Thyroid Hormone, Cortisol, Stress & Depression, Menstrual Cycle, Genetics 00:17:43 Sponsor: AG1 00:19:20 Increase Norepinephrine, Tools: Deliberate Cold Exposure & Exercise 00:21:40 Chronic Inflammation & Depression, Tools: Omega-3s (EPA) & Exercise 00:26:49 Sponsor: Our Place 00:28:41 Tool: Creatine Monohydrate Supplementation & Improving Depression 00:30:20 Novel Depression Therapies, Ketamine, Psilocybin 00:35:29 Ketogenic Diet & Refractory Depression, GABA 00:37:57 Recap & Key Takeaways Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
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  • Welcome to Huberman Lab Essentials,

  • where we revisit past episodes for the most potent and actionable science-based tools for mental health,

  • physical health, and performance.

  • I'm Andrew Huberman,

  • and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.

  • Today, we're discussing depression.

  • In particular, we're going to talk about major depression.

  • The phrase major depression is used to distinguish one form of depression from the other,

  • the other one being bipolar depression.

  • Major depression impacts 5% of the population.

  • That is an enormous number.

  • That means if you're in a class of 100 people,

  • five of them are dealing with major depression or have at some point.

  • Look around you in any environment and you can be sure that a good portion of the people that you're surrounded by is impacted by depression or will be at some point.

  • So this is something we really have to take seriously and that we want to understand.

  • It is the number four cause of disability.

  • A lot of people miss work, miss school,

  • and before then likely perform poorly in work or school due to major depression.

  • So let's talk about the things that are present in somebody that has major depression.

  • First of all, there tends to be a lot of grief.