Essentials: The Science & Treatment of Obsessive Compulsive Disorder (OCD)

essentials:强迫症(OCD)的科学治疗

Huberman Lab

2026-07-09

35 分钟
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单集简介 ...

In this Huberman Lab Essentials episode, I explain the biology and psychology of obsessive-compulsive disorder (OCD) and describe the neural circuitry behind repetitive "thought-action loops," including why compulsive actions actually strengthen the underlying obsessions rather than relieve them. I discuss the most effective treatments for OCD, including exposure-based cognitive behavioral therapy and SSRIs, and explain what the research shows about how these compare when used alone versus together. Finally, I describe a specific clinical protocol in which patients are guided into states of anxiety while learning to suppress compulsive responses, retraining the brain to break the OCD cycle. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Rorra: https://rorra.com/huberman Timestamps (00:00:00) Obsessive-Compulsive Disorder (OCD) (00:00:11) OCD Prevalence & Impact, Obsessions & Compulsions (00:01:54) Categories: Checking, Repetition & Order; Contamination & Disgust (00:04:30) Anxiety, Fear (00:05:20) Sponsor: AG1 (00:06:40) Genetic Component of OCD (00:08:45) Neural Circuitry, Cortex, Striatum, Thalamus (00:10:16) Cortico-Striatal-Thalamic Loop; Imaging Studies, SSRIs (00:14:30) Sponsor: Eight Sleep (00:16:00) Diagnosis, Yale-Brown Obsessive Compulsive Scale (Y-BOCS) (00:18:00) Y-BOCS Categories, Identifying the Core Fear (00:19:30) Tool: Cognitive Behavioral Therapy (CBT) & Exposure Therapy (00:21:39) Anxiety Tolerance, Interrupting the Compulsion (00:23:23) Dr. Helen Blair Simpson, Ritual Prevention, Exposure Sessions (00:25:18) CBT vs Placebo vs SSRIs (00:26:30) Sponsor: Rorra (00:28:07) SSRIs & Serotonin System; Psychiatry & Causality (00:29:13) Cannabis, CBD & OCD; Transcranial Magnetic Stimulation (TMS) (00:31:48) Mindfulness Meditation, Holistic Treatments, NIH (00:33:40) Nutraceuticals, Inositol; Recap & Conclusion Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
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单集文稿 ...

  • Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent

  • and actionable science-based tools for mental health, physical health, and performance.

  • I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.

  • Today, we are talking about obsessive compulsive disorder, or OCD.

  • First of all, as the name suggests, OCD includes thoughts, or obsessions, and compulsions, which are actions.

  • The obsessions and the compulsions are often linked.

  • In fact, most of the time, the obsessions

  • and the compulsions are linked such that the compulsion, the behavior, is designed to relieve the obsession.

  • However, one of the hallmark themes of obsessive compulsive disorder is that the obsessions are intrusive.

  • People don't want to have them.

  • They don't enjoy having them.

  • They just seem to pop into people's minds and they seem to pop into their mind recurrently.

  • And the compulsions, unlike other sorts of behaviors, provide brief relief to the obsession,

  • but then very quickly reinforce or strengthen the obsession.

  • OCD is extremely common.

  • In fact, current estimates are that anywhere

  • from 2.5% to as high as three or even 4% of people suffer from true OCD.

  • That is an astonishingly high number.

  • Another thing to point out is that OCD is currently listed as number seven in terms of the most debilitating illnesses,

  • not just mental illnesses or disorders, but all types of illnesses, including things like asthma and cancer, et cetera.