Rethinking Depression

重新审视抑郁

Hidden Brain

2026-03-17

53 分钟
PDF

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We tend to see depression as an illness to eliminate, evidence that something has gone wrong in the brain. But what if low mood serves a purpose? Psychologist Jonathan Rottenberg examines the evolutionary roots of depression and reflects on his own painful experience with suicidal despair. He explores how depression can narrow our focus, and sometimes open the door to change. A note that this story includes a discussion of suicide. If you or someone you love is struggling with thoughts of suicide, there are people who can help. If you're inside the U.S., call or text 988, or visit the 988 Helpline online. If you’re outside the U.S., you can search for resources in your country on this site. Episode illustration by Runend Art for Unsplash Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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  • This is Hidden Brain.

  • I'm Shankar Vedanta.

  • For centuries, physicians regarded fever as a dangerous disease, an enemy to be crushed.

  • In ancient and medieval medicine,

  • fever was thought to represent an excess of heat or humor in the blood,

  • a sign that the body's internal balance had gone dangerously askew.

  • Treatments aimed to drive out the heat.

  • Patients were bled.

  • purged or doused with cold water.

  • Some were packed in ice or fed diets designed to cool the blood.

  • Well into the 19th century,

  • fever was still widely feared as a destructive force that could consume a person from within.

  • Doctors prescribed mercury-based compounds, quinine or alcohol in large quantities.

  • Patients were subjected to fever cures in which they were submerged in prolonged cold baths or were wrapped in vinegar-soaked sheets,

  • all in the hope of forcing the body's temperature back down.

  • It wasn't until the late 19th and early 20th centuries that scientists began to recognize fever not as a disease,

  • but as a natural response of the body's immune system.

  • Research showed that infections, not fever, were the real enemy.

  • Studies showed that moderate fever actually helped the body fight infection by slowing the growth of bacteria and enhancing immune function.

  • This shift marked a profound change in medical thinking.