The Strange Case Of The Man Immune To Alzheimer’s

阿尔茨海默症免疫者的奇异病例

New Scientist Podcasts

2026-05-08

16 分钟
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Episode 367 Some people are genetically destined to develop Alzheimer’s disease. But one man who carried the devastating mutation seems to have escaped it entirely - and scientists think it may be because of his job.  Doug Whitney inherited the rare variant of a gene that should have caused early-onset Alzheimer’s in his mid-40s. Many of his family members died from it. Instead, he is now 76 years old with no memory problems and no trace of the disease. Researchers investigating his case uncovered a surprising clue: his inadvertent heat exposure while working as a mechanic in ship engine rooms.  Could heat exposure really help shield the brain from Alzheimer’s? What does Doug’s case reveal about the disease? And should we all build a sauna in our backyard? Rowan Hooper is joined by New Scientist reporter Alice Klein to discuss Doug Whitney’s extraordinary case and what it could mean for the future of Alzheimer’s research. To read more about these stories, visit https://www.newscientist.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices
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  • Today I want to talk about a really fascinating man called Doug Whitney.

  • He has a gene which causes early-onset Alzheimer's.

  • It strikes from around the mid-40s, but he's 76 now.

  • Has no memory problems, no other symptoms of Alzheimer's.

  • Other members of his family very sadly have died, but Doug is immune.

  • And scientists have spent years putting him through dozens of different tests to try and find his secret in the hope

  • that it might lead to the discovery of preventative strategies or treatments for Alzheimer's.

  • And for a while, scientists tried to look at genetic protective factors that he might have.

  • But now we seem to have an answer.

  • From New Scientist, this is the world, the universe and us.

  • I'm Dr Rowan Hooper, joined today by Alice Klein.