Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

迭戈·博霍尔克斯 (Diego Bohórquez) 博士:肠感与肠脑轴的科学

Huberman Lab

2024-05-27

2 小时 42 分钟
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单集简介 ...

In this episode, my guest is Dr. Diego Bohórquez, PhD, professor of medicine and neurobiology at Duke University and a pioneering researcher into how we use our ‘gut sense.’ He describes how your gut communicates to your brain and the rest of your body through hormones and neural connections to shape your thoughts, emotions, and behaviors. He explains how your gut senses a range of features such as temperature, pH, the macro- and micronutrients in our foods, and much more and signals that information to the brain to affect our food preferences, aversions, and cravings. Dr. Bohórquez describes his early life in the Amazon jungle and how exposure to traditional agriculture inspired his unique expertise combining nutrition, gastrointestinal physiology, and neuroscience. We discuss how the gut and brain integrate sensory cues, leading to our intuitive “gut sense” about food, people, and situations. This episode provides a scientific perspective into your gut sense to help you make better food choices and, indeed, to support better decision-making in all of life. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman LMNT: https://drinklmnt.com/huberman Helix Sleep: https://helixsleep.com/huberman InsideTracker: https://insidetracker.com/huberman Timestamps 00:00:00 Dr. Diego Bohórquez 00:02:37 Sponsors: Joovv, LMNT & Helix Sleep; YouTube, Spotify & Apple Subscribe 00:06:49 Gut-Brain Axis 00:11:35 Gut Sensing, Hormones 00:15:26 Green Fluorescent Protein; Neuropod Cells & Environment Sensing 00:26:57 Brain & Gut Connection, Experimental Tools & Rabies Virus 00:35:28 Sponsor: AG1 00:37:00 Neuropod Cells & Nutrient Sensing 00:43:55 Gastric Bypass Surgery, Cravings & Food Choice 00:51:14 Optogenetics; Sugar Preference & Neuropod Cells 01:00:29 Gut-Brain Disorders, Irritable Bowel Syndrome 01:03:03 Sponsor: InsideTracker 01:04:04 Gut & Behavior; Gastric Bypass, Cravings & Alcohol 01:07:38 GLP-1, Ozempic, Neuropod Cells 01:11:46 Food Preference & Gut-Brain Axis, Protein 01:21:35 Protein & Sugar, Agriculture & ‘Three Sisters’ 01:25:16 Childhood, Military School; Academics, Nutrition & Nervous System 01:36:15 Plant Wisdom, Agriculture, Indigenous People 01:41:48 Evolution of Food Choices; Learning from Plants 01:48:15 Plant-Based Medicines; Amazonia, Guayusa Ritual & Chonta Palm 01:56:58 Yerba Mate, Chocolate, Guayusa 02:00:22 Brain, Gut & Sensory Integration; Variability 02:06:01 Electrical Patterns in Gut & Brain, “Hangry” 02:12:43 Gut Intuition, Food & Bonding; Subconscious & Superstition 02:22:00 Vagus Nerve & Learning, Humming 02:26:46 Digestive System & Memory; Body Sensing 02:32:51 Listening to the Body, Meditation 02:40:12 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Social Media, Neural Network Newsletter Disclaimer
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单集文稿 ...

  • Welcome to the Huberman Lab podcast, where.

  • We discuss science and science based tools for everyday life.

  • I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.

  • My guest today is Doctor Diego Borquez.

  • Doctor Diego Borquez is a professor of medicine and neurobiology at Duke University.

  • He did his training in gastrointestinal physiology and nutrition, and later neuroscience.

  • And by combining that unique training and expertise, he is considered a pioneer and leader in so called gut sensing, or the gut brain axis.

  • Now, when most people hear the words gut brain axis, they immediately think of the so called microbiome, which is extremely important.

  • But that is not the topic of doctor Borges expertise.

  • Doctor Borquez focuses on the actual sensing that occurs within one's gut, just as one would sense light with their eyes or sound waves with their ears for hearing.

  • Our gut contains receptors that respond to specific components of food, including amino acids, fats, sugars and other aspects of food, including temperature, acidity and other micronutrients that are contained in food.

  • That give our gut the clear picture of what is happening at the level of the types and qualities of food that we ingest, and then communicate that below our conscious detection to our brain in order to drive specific patterns of thinking, emotion and behavior.

  • And of course, everybody has heard of our so called gut sense, or our ability to believe or feel certain things based on perceptions that are of below or somehow different from conventional language.

  • Today, doctor Borges teaches us about all aspects of gut sensing.

  • How it occurs at the level of specific neurons and neural circuits, how the brain responds to that, how specific foods and components of food impact not just our feeling of digestion, or feeling good or bad about what we ate, but indeed how we feel overall.

  • How safe we feel, how excited we feel, whether or not we feel depressed or sad, angry or happy.

  • Today's discussion, I promise you, is unique among all discussions of neuroscience, at least that I've heard previously, in that it combines two seemingly disparate nutrition and neuroscience.

  • Indeed, today's discussion gets into how different foods and food combinations impact how we feel and what we crave, and what we tend to avoid.

  • We also get to hear the absolutely extraordinary story of Doctor Borque's upbringing in the Amazon jungle, and how his knowledge and intuition about plants has influenced his science, and how the incredible science that his laboratory is doing relates to all of us, and our ability to better tap into our gut sense.

  • Before we begin, I'd like to emphasize that this podcast is separate from my teaching and research roles at Stanford.