2024-07-29
2 小时 30 分钟Welcome to the Huberman Lab podcast, where we discuss science and science based tools for everyday life.
I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.
My guest today is Doctor Peter Attia.
Doctor Peter Attia is a medical doctor who did his training at Stanford University School of Medicine and Johns Hopkins School of Medicine.
Doctor Attia is one of the world's most trusted voices on the topics of health span and lifespan, and with good reason.
He is known to systematically review the research literature, the clinical trials, and he maintains an avid clinical practice.
So when it comes to the topic of whether or not a particular molecule or supplement or prescription drug is indeed something that we should be thinking about and perhaps even taking in order to improve our health span and lifespan, Doctor Attia is the person that I choose to sit down with and discuss it.
So today we are going to discuss the so called Nad pathway.
This is a pathway that's received a lot of attention in recent years as a potential target for improving lifespan, that is, for living longer.
Today, we discuss the various molecules in this pathway and the various approaches to increasing NAD, which is the end target goal of anyone that's trying to augment the NAD pathway, so to speak.
So, for instance, we talk about taking NR versus NMN versus direct infusions, or even orally taking NAD, and we compare them in terms of both what's known and what is not known about their ability to get into cells and any efficacy they may have for either longevity or health span.
Doctor Attia and I compare and contrast the literature on this, again, both research and clinical literature, and we discuss whether or not he or I take NAD, NMN or NR, and if so, or if not, the reasons for that.
We also each go through our own supplement regimen, which, of course, reflects what we do believe can potentially have an effect on health span and or lifespan.
So by the end of today's episode, you'll learn a lot about naddemen, you'll learn a lot about the biological pathway, you'll learn a lot about the delivery routes, the various supplements, and why people think they may be useful, why others, perhaps even Doctor Attia and myself, think they may not be useful for longevity.
You'll have to listen to find out what the answer is there.
I should also mention that we give somewhat of an overview or a framework for thinking about approaches to longevity.
So if you're interested in things like rapamycin, metformin, and whether or not fasting can improve longevity, we get into that as well.
Before we begin, I'd like to emphasize that this podcast is separate from my teaching and research roles at Stanford.
It is, however, part of my desire and effort to bring zero cost to consumer information about science and science related tools to the general public.
In keeping with that theme, I'd like to thank the sponsors of today's podcast.